NO.65 TOPICAL FILLER

The First Regenerative Topical Filler

No.65 Cream like formula is a revolutionary bio-stimulatory formula developed with our most advanced patented technology to induce dermal regeneration. By activating key cellular pathways, No.65 stimulates fibroblast activity, increases collagen synthesis, and restores skin density, firmness, and youthful volume from within.

Formulated with bioactive nano–Calcium Hydroxyapatite (CaP) core nanoparticles, utilizing ultra-fine 65 nm particles designed for deeper penetration and superior regenerative performance. Through calcium ion signaling, these nanoparticles activate the Calcium-Sensing Receptor (CaSR) on fibroblasts, leading to increased type I collagen production, while released phosphate ions support ATP synthesis and enhance cellular metabolism.

The controlled interaction of nano-CaP particles with keratinocytes and fibroblasts further promotes extracellular matrix (ECM) remodeling, resulting in progressive skin densification and refined texture improvement without adding bulk volume. The advanced nano-delivery system ensures sustained bio-stimulation and long-term regenerative effects.

Ideal for improving skin laxity, loss of density, and visible signs of aging, No.65 enhances overall skin quality, firmness, and radiance through physiological collagen remodeling rather than volumization.

KEY INGREDIENTS:

• Nano–Calcium Hydroxyapatite (CaP): Activates fibroblasts, stimulates type I collagen production, and supports extracellular matrix remodeling.
  

KEY BENEFITS:

• Stimulates collagen production and dermal regeneration
  
• Improves skin density, firmness, and elasticity
  
• Enhances skin texture and surface smoothness
  
• Provides regenerative and optical skin-enhancing effects
  
• 65 nm average particle size for optimal penetration
  
• 0.3 mm dermal delivery depth
  
• Visible collagen remodeling within 6–8 weeks
  

Suitable For:

• Skin with loss of firmness and density
  
• Aging or photo-aged skin
  
• Skin with compromised texture and elasticity
  
• All skin types, including sensitive skin
  

Directions for Use:

• After cleansing, apply an appropriate amount evenly to the face.
  
• Gently massage until fully absorbed.
  
• Use once at night.
  
• Follow with sunscreen during the day.
  

Warnings:

• For external use only.
  
• Avoid contact with eyes; if contact occurs, rinse thoroughly with clean water.
  
• Discontinue use if persistent redness or irritation develops.
  
• Do not apply to broken or actively inflamed skin.
  
• Keep out of reach of children.
  
• Store in a cool, dry place, away from direct sunlight or excessive heat.
  

Note:
Dermatologically tested.
Free For parabens, sulfates, alcohol, and artificial fragrance.
Cruelty-free, non-comedogenic, and suitable for sensitive skin.
Formulated with eco-friendly active ingredients to ensure maximum skin compatibility and long-term skin health.